Sexual Assault Nurse Examiner (SANE) A Practice Exam

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In which situation might initiating NPEP be indicated regardless of test results?

  1. When the patient needs immediate treatment

  2. When there is uncertainty about the patient's health history

  3. If the patient expresses a worry about HIV

  4. If the exposure source is known and at low risk

The correct answer is: When the patient needs immediate treatment

Initiating Non-Occupational Post Exposure Prophylaxis (NPEP) is critical in situations where there is an immediate need to prevent HIV infection after a potential exposure. This is because NPEP is time-sensitive; it is most effective when started within 72 hours of exposure to the virus. Therefore, a patient needing immediate treatment, especially after a high-risk exposure, warrants the initiation of NPEP regardless of their test results. The other scenarios mentioned do not provide sufficient justification for the immediate administration of NPEP. Uncertainty about the patient's health history or a patient's worries about HIV could lead to consideration for NPEP, but they do not meet the urgency required for immediate treatment. Similarly, if the exposure source is known and deemed to be at low risk, it may lead to a decision against NPEP; hence, immediate initiation would not be justified in such a case. Thus, the emphasis on immediate treatment in response to clear, high-risk exposure supports the appropriateness of NPEP in this context.